When in doubt call the pharmacist. But, my answer would be yes. Amoxicillan is an antibiotic. Tylenol Cold has Acetometiphine (pain killer/fever reducer), and probably an antihistimine (dries up the mucus) and/or a decongestant (thins the mucus secretions). As long as your medicines are not doubling up on any of these ingredients you can take them together.