I wrote out my answer and by the time I posted the response you deleted your question.
DON'T LET RUDE PEOPLE MAKE YOU DELETE YOUR QUESTION.
Here is the answer now. Around 6 months they will be mature enough too, however it is not recomended until the dog is around 2 years old and can have tests done to make sure they are in good health all around (hips, eyes, heart, lungs that kind of thing).
I would google dog breeding and breeding great danes and educate yourself on it before you do it :)
Make sure you are ready to devote 6-12 weeks to taking care of puppies, and you are ready to devote yourself to making sure the puppies find good loving homes!!
NOW I hate when people tell others to get their pets spayed and neutured. It is rude. It is not your pet, you didn't pay for it, you didn't take care of it, train it, love it, and take it to the vet. So don't worry about what others are doing with their pets. Gosh
Answer by Anonymous at 2:00 PM on Apr. 22, 2009
Answer by Anonymous at 3:39 PM on Apr. 22, 2009
Answer by Anonymous at 12:37 PM on Apr. 23, 2009
Answer by melody77 at 5:49 PM on Apr. 23, 2009