The signs of pregnacy, peri-menopause, and PMS are pretty much the same. If you are over 40, have a negative pregnancy test in hand (after properly following the directions, including waiting until you are a certain number of days late) then I'd guess peri-menopause. Menopause itself (all the years after your last period ends) may still be a decade or more away.
at 12:44 PM on Jun. 14, 2009