My entire family has Eczema. Me, SO, both the boys & the new baby will probably have it once she's born. I use OxyClean all the time. The spray and the powder. And I use my regular tide. I've never seen a problem. No extra dryness or any rashes, etc. Even though our Ezcema is bad, everyones case is different so you won't know until you try. But for my family we haven't seen an issue yet.