I took SAM-E for several months. It worked okay, but gave me headaches. Then I tried St John's Wort. (I had read that it is widely prescribed in Europe and has few side-effects.) It worked for the depression, but reduces the effects of oral contraception.
What worked best for me was getting my thyroid under control, and (here's the HARD one) cutting waaaaaay back on sweets. Also regular exercise and meditation actually help a lot. But still, if I have a really sugary dessert, the next day my mood is low.
I would think twice about Rx antidepressants. Their efficacy has been proven spotty in double blind testing, and most have some pretty nasty side-effects; particularly in young adults. Like: suicide. Listen to the long list of crappy side -effects they spew on their commercials. :-\
at 1:22 AM on Oct. 13, 2010