Depends on what you want.
The Vampire Chronicles is her seminal work. A series of 10 books, spanning pretty much all of creation - from the creation of man to the creation of the vampires. Interview with the Vampire is the first in the series. If you've seen the movie, it makes it a good place to start, since you'll have a decent (although minimal) understanding of the arc of the tale. But it's not the best in the series by far.
She also written some erotica (under the names Anne Rampling and A.N. Roqulaire) and some....'Christian' novels. The Christ the Lord series is interesting - it's starts with Jesus as a young boy who is just beginning to realize he is different from other children.
at 9:51 AM on Nov. 27, 2010