My sister and I have been estranged for about 11 years, going on 12. We had a disagreement after I had my youngest child.
It's a very, very long story, but the bottom line is that she stopped speaking to me after I invited her to take photos at the homebirth of my daughter. She accused me of stealing "her photos" because I wouldn't let her keep all the photos she took. (I was naked, for one thing, and for another, she told me she wanted to show them to people!) We have barely spoken in the past 11 years (one email exchange and a few sentences in person).
Are you estranged from anyone? Have you tried to make things right?