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Trazadone

Posted by on Jul. 12, 2012 at 11:56 AM
  • 8 Replies
Is this safe for breastfeeding?
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Posted by on Jul. 12, 2012 at 11:56 AM
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battisarah
by Bronze Member on Jul. 12, 2012 at 8:32 PM
Bump
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mostlymaydays
by Group Mod-Stacy on Jul. 12, 2012 at 8:37 PM
I had taken trazodone between babies to help me sleep but my dr didn't think it was ok during a pregnancy or bfing, though I don't trust reg drs to know this. Call Dr Hales Infant risk hotline. But this is from my Lactmed app:

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One infant whose mother took trazodone 200 mg daily for 12 weeks starting at 4 weeks postpartum was followed up at 12 months of age. No adverse effects on growth and development were found.[3]

One woman was 6.5 weeks postpartum and taking trazodone 75 mg, venlafaxine 75 mg and quetiapine 75 mg daily before conception, during pregnancy and during breastfeeding. Her breastfed infant's development was tested at 12 months of age with the Bayley Scales. Measurements were within normal limits on the mental, psychomotor and behavior scales.[2]

One exclusively breastfed 15-week-old infant was breastfed during maternal therapy with trazodone 100 mg daily and venlafaxine 150 mg daily. No adverse reactions were reported by the mother or in the medical records.[4]
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mostlymaydays
by Group Mod-Stacy on Jul. 12, 2012 at 8:39 PM
Also from LactMed:

Limited information indicates that trazodone levels in milk are low and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months or when doses of 100 mg or less are used at bedtime for sleep.
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mostlymaydays
by Group Mod-Stacy on Jul. 12, 2012 at 8:40 PM
No shock but it seems as my doctor was wrong. I think it might be more of an issue for cosleeping than breastfeeding. If you're taking it to help your sleep cycle.
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Starr0617
by Member on Jul. 13, 2012 at 5:20 AM

I would not suggest it...call your baby's pedi to double check. There are a lot of meds that are considered 'ok' to take but with out an MD behind your name I dont advise making that choice, at least I wouldn't, That is your childs life you are risking. Trazadone is a med that I would be very iffy with anyways...think about how it effects you..and the same effects on your baby. I would say call your Dr and the Pedi...no point in risking it at all.

gdiamante
by Group Mod - Gina on Jul. 13, 2012 at 11:29 AM
2 moms liked this

Actually, Starr, doc and ped are the WORST resources for that kind info most of the time. They don't know... they just say no because it's easier.

The LactMed source quoted above is like getting the Ten Commandments from Moses himself; LactMed is a database run by the National Institutes of Health. They aggregate all the research out there to provide accurate info rather than simply saying no because it's easier.

Quoting Starr0617:

I would not suggest it...call your baby's pedi to double check. There are a lot of meds that are considered 'ok' to take but with out an MD behind your name I dont advise making that choice, at least I wouldn't, That is your childs life you are risking. Trazadone is a med that I would be very iffy with anyways...think about how it effects you..and the same effects on your baby. I would say call your Dr and the Pedi...no point in risking it at all.


Starr0617
by Member on Jul. 13, 2012 at 2:31 PM

I dont know if you ladies just have shitty Doc's or what..but my Doc's always check their little black book on all my medication, simply because I am on so many they have to be sure...I am taking all but one of mine...so no my MD's dont just say no. I trust the Dr's thats just me though.

Quoting gdiamante:

Actually, Starr, doc and ped are the WORST resources for that kind info most of the time. They don't know... they just say no because it's easier.

The LactMed source quoted above is like getting the Ten Commandments from Moses himself; LactMed is a database run by the National Institutes of Health. They aggregate all the research out there to provide accurate info rather than simply saying no because it's easier.

Quoting Starr0617:

I would not suggest it...call your baby's pedi to double check. There are a lot of meds that are considered 'ok' to take but with out an MD behind your name I dont advise making that choice, at least I wouldn't, That is your childs life you are risking. Trazadone is a med that I would be very iffy with anyways...think about how it effects you..and the same effects on your baby. I would say call your Dr and the Pedi...no point in risking it at all.



maggiemom2000
by Ruby Member on Jul. 14, 2012 at 11:06 PM

The following information comes from MEDICATIONS AND MOTHERS’ MILK by Thomas Hale, 2010.  He assigns every drug a lactation risk category:  L1, safest; L2, safer; L3, moderately safe; L4, possible hazardous; and L5, contraindicated. He also lists if a drug has been reviewed and/or approved by the American Academy of Pediatrics (AAP) for use in nursing mothers.  Possible risks to mother and baby are listed as well as possible effect on milk supply.


For more info you can call Dr. Hale’s InfantRisk hotline at (806) 352-2519


www.infantrisk.org

TRAZODONE (Desyrel)


Listed as L2, safer; AAP: Drugs whose effect on nursing infants is unknown but may be of concern; Pediatric concerns: None reported via milk.


Trazadone is an antidepressant whose structure is dissimilar to the triciclics and to the other antidepressants. In six mothers who received a single 50mg dose, the milk/plasma ratio averaged 0.14. Peak milk concentrations occured at 2 hours and were approximately 110 ug/L and declined rapily thereafter. On a weight basis, an adult would receive 0.77 mg/kg whereas a breastfeeding infant, using this data, would consume only 0.005 mg/kg. The authors estimate that about 0.6% of the maternal dose was ingested by the infant over 24 hours.

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