HPV vaccination programs have not been shown to be cost-effective in countries with comprehensive Pap screening and surgery
In the pre-licensure trials adverse events were only actively monitored for 15 days after vaccination . However, in the post-licensure passive surveillance system events were reported that occurred weeks or months after vaccination . It is known that the effects of the chemicals in the vaccines can be latent and appear weeks, months or years after administration [33,34]. The researchers themselves claim that the surveillance system is severely limited . The limitations include:
I. It is a passive system so events are underreported.
II. Not all reported events are systematically validated.
III. Inconsistency in the quality and completeness of reported data.
IV. Reporting biases.
VAERS received 12 424 reports of AEFIs following qHPV distribution, a rate of 53.9 reports per 100,000 doses distributed. A total of 772 reports (6.2% of all reports) described serious AEFIs, including 32 reports of death.