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My vaccine schedule, not their's

I am not totally against vaccines. Most I feel are unnecessary. However I do think it's the safest thing, for my childeren, to get a few. However, I do delay them.

DTap delayed until 6 months
PCV delayed until 6 months
Hib delayed until 6 months
IPV delyaed until 9 months
MMR Delayed until 12 months

by on Mar. 8, 2014 at 4:55 PM
Replies (31-35):
Jennacat
by Member on Mar. 18, 2014 at 8:39 AM

You are giving your baby 3 different vaccines at 6 months. That's hard for a little body to take.


Jennacat
by Member on Mar. 18, 2014 at 8:42 AM

BTW, you are not stupid. I have a lot of respect for you. You genuinely want what's best for your child and you are open to suggestions. Most people won't even listen. Kudos to you!

emmy526
by New Owner on Mar. 18, 2014 at 8:49 AM

not only that, it's more than three vaccines...it's at least 5 diseases at once, not to mention the antigens involved.  Diptheria, Tetanus, Pertussis, HIB, and pcv13, which is known for serotype replacement and causing antibiotic resistant ear infections. 

Quoting Jennacat:

You are giving your baby 3 different vaccines at 6 months. That's hard for a little body to take.



emmy526
by New Owner on Mar. 18, 2014 at 1:30 PM
emmy526
by New Owner on Mar. 20, 2014 at 9:30 AM

Pneumococcal Conjugate Vaccine: Implications for Nasopharyngeal Carriage and Respiratory Disease, Resistance and Disease Transmission

Faculty and Disclosures

PNEUMOCOCCAL CONJUGATE VACCINE: IMPLICATIONS FOR NASOPHARYNGEAL CARRIAGE AND RESPIRATORY DISEASE, RESISTANCE AND DISEASE TRANSMISSION

Nasopharyngeal Carriage in Pnc Conjugate Vaccine Recipients Presented by Ron Dagan, MD


I will try to convince you that the effect of the vaccine on the nasopharynx in terms of reduction and modification of the carriage rate of pneumococci is a key factor to understanding what's going on beyond the invasive infection because the outcome of pneumococcus is much more complex than one can think and discuss.

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We all know that pneumococcus resides in the nasopharynx. From there, it can spread to mucosal infection such as sinusitis, pneumonia or otitis media. It can invade the bloodstream, or very importantly, can spread from 1 person to another, from 1 enterprise to another.

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Therefore, it is important to understand first that there are many investigators, many vaccines, many sites, and many age groups, but no matter which study you look at, all demonstrate the reduction of the carriage rate, or nasopharyngeal carriage rate, of a pneumococci of serotypes that are in the vaccine. We call them the vaccine types.

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There's always a reduction in carriage rate no matter which vaccine and which population is studied. I will try to show you that this reduction in carriage of the vaccine types is related to 4 different phenomena. One is a reduction of antibiotic resistance among pneumococci that we see now; another one is replacement phenomenon, which means that one serotype is decreasing, but another one comes instead. Modification of disease can be expected if antibiotic resistance is changing and we have replacement; then we should see whatever it is late after the vaccination, we see something different. A final phenomenon is herd protection. It's not really herd immunity like a lot of people say because herd immunity means that the herd gets immunized by immunizing some other people. It's herd protection, which means that contacts of the immunized child will not get disease or will get less disease because the child will transmit less.

These phenomena are really interrelated, and they're all related to the nasopharyngeal carriage.

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Antibiotic Resistance in Invasive Pnc


Let's start with antibiotic resistance. We know that a carriage of resistant pneumococci is quite common. We know that since the nasopharyngeal carriage is the stop point for everything, and otitis is the number 1 cause of antibiotic prescription.

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Carriage of resistant pneumococci is associated with disease, with resistant pneumococci, which increases the failure rate, which in turn increases antibiotic use, which promotes more resistance. You have a vicious cycle that has to be stopped somehow.

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We know that these serotypes, 6B, 9V, 14, 19F, and 23F, which are included in PCV7, but they're also going to be included in any one of the 9-valent, or 11-valent vaccines, are the most important in terms of resistance.

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First there are the most common serotypes to cause respiratory infections and even in many places in the world invasive disease, but we're talking now about respiratory infections, so these actually show you that no matter if you go to Kentucky in the United States or to Israel you can see very clearly that they are very similar if there are cultures taken from children who have tympanocentesis.

So it's a little bit more severe than usual disease, but still you see how common they are and how similar they are on both sides of the ocean. And, therefore, these 5 serotypes are not only the most resistant ones but also the most common ones.

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The 9-valent vaccine is exactly like the 7-valent, but it comes with another 2 serotypes, serotypes 1 and 5. The 11-valent comes with an additional 2 serotypes, 3 and 7F. Otherwise, both the 9-valent and the 11-valent vaccines contain the same serotypes as the 7-valent. This is from a study in Israel that had 831 consecutive otitis media cases from which we isolated pneumococcus from the middle-ear fluid.

The 7-valent vaccine really doesn't cover much of all susceptible pneumococci. Even the 11-valent doesn't get to 50%. But when you go to penicillin it's immediately resistant, and the 7-valent covers almost 70% and there's not much difference between the vaccines because this is mainly due to these 5 serotypes, the 6B, 9V, 14, 19F, and 23F.

When you go to high-penicillin resistance, you see clearly that over 90% are covered just by these vaccines because this is even more concentrated with these 5 serotypes.

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This is a study done in the United States in which 500 isolates were examined for multi-resistance. You can see there's a more common pattern here -- penicillin, azithromycin and trimethoprim sulfa -- and you can see that the most common serotypes are 14, 19F, 23F, 6B, and 9V, the 5 biggies. The other ones are 19A and 6A, and those can be covered or can be reduced somehow by the vaccine, thought it may not be as effectiveness as for the vaccine types.

If you look at all the others, they're not really much, so actually 90% of high resistance and multiple resistance is covered by the vaccine. This is the good news.

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And if you remember that we have a reduction of the vaccine types from the nasopharynx, you can then understand very clearly that there is also a reduction in resistance because of those 5 serotypes. So it's very clear that the vaccine reduces carriage of antibiotic-resistant pneumococci.

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continues in link

  http://www.medscape.org/viewarticle/445087_2
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