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Baby Born With HIV Apparently Cured, Say Scientists

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Baby Born With HIV Apparently Cured, Say Scientists

By LAURAN NEERGAARD 03/03/13 04:34 PM ET EST AP

WASHINGTON -- A baby born with the AIDS virus appears to have been cured, scientists announced Sunday, describing the case of a child from Mississippi who's now 2 1/2 and has been off medication for about a year with no signs of infection.

There's no guarantee the child will remain healthy, although sophisticated testing uncovered just traces of the virus' genetic material still lingering. If so, it would mark only the world's second reported cure.

Specialists say Sunday's announcement, at a major AIDS meeting in Atlanta, offers promising clues for efforts to eliminate HIV infection in children, especially in AIDS-plagued African countries where too many babies are born with the virus.

"You could call this about as close to a cure, if not a cure, that we've seen," Dr. Anthony Fauci of the National Institutes of Health, who is familiar with the findings, told The Associated Press.

A doctor gave this baby faster and stronger treatment than is usual, starting a three-drug infusion within 30 hours of birth. That was before tests confirmed the infant was infected and not just at risk from a mother whose HIV wasn't diagnosed until she was in labor.

"I just felt like this baby was at higher-than-normal risk, and deserved our best shot," Dr. Hannah Gay, a pediatric HIV specialist at the University of Mississippi, said in an interview.

That fast action apparently knocked out HIV in the baby's blood before it could form hideouts in the body. Those so-called reservoirs of dormant cells usually rapidly reinfect anyone who stops medication, said Dr. Deborah Persaud of Johns Hopkins Children's Center. She led the investigation that deemed the child "functionally cured," meaning in long-term remission even if all traces of the virus haven't been completely eradicated.

Next, Persaud's team is planning a study to try to prove that, with more aggressive treatment of other high-risk babies. "Maybe we'll be able to block this reservoir seeding," Persaud said.

No one should stop anti-AIDS drugs as a result of this case, Fauci cautioned.

But "it opens up a lot of doors" to research if other children can be helped, he said. "It makes perfect sense what happened."

Better than treatment is to prevent babies from being born with HIV in the first place.

About 300,000 children were born with HIV in 2011, mostly in poor countries where only about 60 percent of infected pregnant women get treatment that can keep them from passing the virus to their babies. In the U.S., such births are very rare because HIV testing and treatment long have been part of prenatal care.

"We can't promise to cure babies who are infected. We can promise to prevent the vast majority of transmissions if the moms are tested during every pregnancy," Gay stressed.

The only other person considered cured of the AIDS virus underwent a very different and risky kind of treatment – a bone marrow transplant from a special donor, one of the rare people who is naturally resistant to HIV. Timothy Ray Brown of San Francisco has not needed HIV medications in the five years since that transplant.

The Mississippi case shows "there may be different cures for different populations of HIV-infected people," said Dr. Rowena Johnston of amFAR, the Foundation for AIDS Research. That group funded Persaud's team to explore possible cases of pediatric cures.

It also suggests that scientists should look back at other children who've been treated since shortly after birth, including some reports of possible cures in the late 1990s that were dismissed at the time, said Dr. Steven Deeks of the University of California, San Francisco, who also has seen the findings.

"This will likely inspire the field, make people more optimistic that this is possible," he said.

In the Mississippi case, the mother had had no prenatal care when she came to a rural emergency room in advanced labor. A rapid test detected HIV. In such cases, doctors typically give the newborn low-dose medication in hopes of preventing HIV from taking root. But the small hospital didn't have the proper liquid kind, and sent the infant to Gay's medical center. She gave the baby higher treatment-level doses.

The child responded well through age 18 months, when the family temporarily quit returning and stopped treatment, researchers said. When they returned several months later, remarkably, Gay's standard tests detected no virus in the child's blood.

Ten months after treatment stopped, a battery of super-sensitive tests at half a dozen laboratories found no sign of the virus' return. There were only some remnants of genetic material that don't appear able to replicate, Persaud said.

In Mississippi, Gay gives the child a check-up every few months: "I just check for the virus and keep praying that it stays gone."

The mother's HIV is being controlled with medication and she is "quite excited for her child," Gay added.

by on Mar. 3, 2013 at 5:59 PM
Replies (11-20):
TranquilMind
by Platinum Member on Mar. 3, 2013 at 11:35 PM
1 mom liked this

 Well, I have a doctorate, but am not a medical doctor.  However, I can read research and have paid attention to this issue since it became big back in the 80's.  Mothering ran extensive articles on this back when they were arresting HIV positive Moms for breastfeeding.

I actually thought this might have been a substantive response.  I should know better.

  If you object to my idea, attack the idea.  Cussing me out does not bolster your position and it does discredit to your screen name, which I assume you think represents you.

Have a good night.

 

Quoting Goodwoman614:

 

 

Quoting TranquilMind:

The baby may well have sero-converted without all this poisonous treatment. 

It's happened regularly since the 80's.  Nothing new. 

Here's something I saw:

http://www.accessexcellence.org/WN/SUA03/hiv_baby_seroconverts.php

 

Are you a doctor? 

Then shut the f*ck up.

 

 

toomanypoodles
by Ruby Member on Mar. 3, 2013 at 11:49 PM

 Wow....let's pray that this is one wicked disease that can finally be cured. 

Goodwoman614
by Satan on Mar. 4, 2013 at 12:09 AM



Quoting TranquilMind:

 Well, I have a doctorate, but am not a medical doctor.  However, I can read research and have paid attention to this issue since it became big back in the 80's.  Mothering ran extensive articles on this back when they were arresting HIV positive Moms for breastfeeding.

I actually thought this might have been a substantive response.  I should know better.

  If you object to my idea, attack the idea.  Cussing me out does not bolster your position and it does discredit to your screen name, which I assume you think represents you.

Have a good night.


Quoting Goodwoman614:



Quoting TranquilMind:

The baby may well have sero-converted without all this poisonous treatment. 

It's happened regularly since the 80's.  Nothing new. 

Here's something I saw:

http://www.accessexcellence.org/WN/SUA03/hiv_baby_seroconverts.php


Are you a doctor? 

Then shut the f*ck up.




So wow. "I'm not a doctor(MD), but I play one in my mind. Because, hey, I've read about this!"

And so you feel perfectly justified to come on here & just throw out some biggg worrrrds you read about, like, ooooh aaaahhhhh: 'sero-converrrrrrsion.'

So I say again, STFU.

TranquilMind
by Platinum Member on Mar. 4, 2013 at 12:19 AM
1 mom liked this

 I see that reading comprehension is difficult for you, but you are well-versed in using vulgar curse words in a futile attempt to distract from the fact that you have nothing substantive to add.   

I hope this serves you well.  

Duly noted.

And how many degrees do you have? 

Yeah, I thought so. 


 

Quoting Goodwoman614:

 

 

Quoting TranquilMind:

 Well, I have a doctorate, but am not a medical doctor.  However, I can read research and have paid attention to this issue since it became big back in the 80's.  Mothering ran extensive articles on this back when they were arresting HIV positive Moms for breastfeeding.

I actually thought this might have been a substantive response.  I should know better.

  If you object to my idea, attack the idea.  Cussing me out does not bolster your position and it does discredit to your screen name, which I assume you think represents you.

Have a good night.

 

Quoting Goodwoman614:

 

 

Quoting TranquilMind:

The baby may well have sero-converted without all this poisonous treatment. 

It's happened regularly since the 80's.  Nothing new. 

Here's something I saw:

http://www.accessexcellence.org/WN/SUA03/hiv_baby_seroconverts.php

 

Are you a doctor? 

Then shut the f*ck up.

 

 

 

So wow. "I'm not a doctor(MD), but I play one in my mind. Because, hey, I've read about this!"

And so you feel perfectly justified to come on here & just throw out some biggg worrrrds you read about, like, ooooh aaaahhhhh: 'sero-converrrrrrsion.'

So I say again, STFU.

 

 

Goodwoman614
by Satan on Mar. 4, 2013 at 12:21 AM



Quoting TranquilMind:

 I see that reading comprehension is difficult for you, but you are well-versed in using vulgar curse words to distract from the fact that you have nothing substantive to add.   

I hope this serves you well.  


 

Quoting Goodwoman614:



Quoting TranquilMind:

 Well, I have a doctorate, but am not a medical doctor.  However, I can read research and have paid attention to this issue since it became big back in the 80's.  Mothering ran extensive articles on this back when they were arresting HIV positive Moms for breastfeeding.

I actually thought this might have been a substantive response.  I should know better.

  If you object to my idea, attack the idea.  Cussing me out does not bolster your position and it does discredit to your screen name, which I assume you think represents you.

Have a good night.


Quoting Goodwoman614:



Quoting TranquilMind:

The baby may well have sero-converted without all this poisonous treatment. 

It's happened regularly since the 80's.  Nothing new. 

Here's something I saw:

http://www.accessexcellence.org/WN/SUA03/hiv_baby_seroconverts.php


Are you a doctor? 

Then shut the f*ck up.




So wow. "I'm not a doctor(MD), but I play one in my mind. Because, hey, I've read about this!"

And so you feel perfectly justified to come on here & just throw out some biggg worrrrds you read about, like, ooooh aaaahhhhh: 'sero-converrrrrrsion.'

So I say again, STFU.




The substance I added was directed to you. I feel confident you comprehended it, even if you didn't address it, busy as you were with your ad hominem.

TranquilMind
by Platinum Member on Mar. 4, 2013 at 12:26 AM
1 mom liked this

 

Edited:  On second thought, never mind.  There is simply no point to readdressing something with someone who believes a reasonable response to my comment that "babies have been documented to sero-convert since the 80's when they were arresting breastfeeding HIV positive mothers (including a source)" is ...your comment, which was "stfu".

Like that great theologian said...."You've got to know when to hold 'em, know when to fold 'em, know when to walk away, know when to run...."

(Yes, I know Kenny Rogers wasn't a theologian.  That's a joke.  "Sometimes older people make jokes" (said Tina Fey, as the teacher in Mean Girls)

 

 

Quoting Goodwoman614:

 

 

Quoting TranquilMind:

 I see that reading comprehension is difficult for you, but you are well-versed in using vulgar curse words to distract from the fact that you have nothing substantive to add.   

I hope this serves you well.  


 

Quoting Goodwoman614:

 

 

Quoting TranquilMind:

 Well, I have a doctorate, but am not a medical doctor.  However, I can read research and have paid attention to this issue since it became big back in the 80's.  Mothering ran extensive articles on this back when they were arresting HIV positive Moms for breastfeeding.

I actually thought this might have been a substantive response.  I should know better.

  If you object to my idea, attack the idea.  Cussing me out does not bolster your position and it does discredit to your screen name, which I assume you think represents you.

Have a good night.

 

Quoting Goodwoman614:

 

 

Quoting TranquilMind:

The baby may well have sero-converted without all this poisonous treatment. 

It's happened regularly since the 80's.  Nothing new. 

Here's something I saw:

http://www.accessexcellence.org/WN/SUA03/hiv_baby_seroconverts.php

 

Are you a doctor? 

Then shut the f*ck up.

 

 

 

So wow. "I'm not a doctor(MD), but I play one in my mind. Because, hey, I've read about this!"

And so you feel perfectly justified to come on here & just throw out some biggg worrrrds you read about, like, ooooh aaaahhhhh: 'sero-converrrrrrsion.'

So I say again, STFU.

 

 

 

The substance I added was directed to you. I feel confident you comprehended it, even if you didn't address it, busy as you were with your ad hominem.

 

 

Goodwoman614
by Satan on Mar. 4, 2013 at 12:29 AM

To get back to the OP: 

I am looking forward to how this news will be applied to future therapy best practices protocol for treatment of neonates. I am not sure what the breakdown in costs are for this treatment, should it be adopted by the various recommending agencies that are pivotal in forming such policy. One can only hope that it will be made in reach for the countries (sub-Saharan Africa, India) that need it the most.

This has been a devastating virus to babies born infected, primarily in those same countries that lack in consistent primary medical care for pregnant women.

Goodwoman614
by Satan on Mar. 4, 2013 at 12:50 AM



Quoting TranquilMind:

 Lol.  You just demonstrated that you are unfamiliar with the concept of ad hominem attack.    You leveled an ad hominem attack at me (impugning my credentials AND cursing me out) after I stated that sero-conversion is nothing new, as it has been documented for the last 30 years. 

Um, stating that this is nothing new, and citing a source is most decidedly NOT an ad hominem attack.  Telling someone to stfu because you have nothing substantive to add IS an ad hominem attack.  

 There is easy access to a dictionary online, if you are uncertain about a term.  Use it.  Comes in handy. 

And on that humorous note...time for bed. 

Quoting Goodwoman614:



Quoting TranquilMind:

 I see that reading comprehension is difficult for you, but you are well-versed in using vulgar curse words to distract from the fact that you have nothing substantive to add.   

I hope this serves you well.  


 

Quoting Goodwoman614:



Quoting TranquilMind:

 Well, I have a doctorate, but am not a medical doctor.  However, I can read research and have paid attention to this issue since it became big back in the 80's.  Mothering ran extensive articles on this back when they were arresting HIV positive Moms for breastfeeding.

I actually thought this might have been a substantive response.  I should know better.

  If you object to my idea, attack the idea.  Cussing me out does not bolster your position and it does discredit to your screen name, which I assume you think represents you.

Have a good night.


Quoting Goodwoman614:



Quoting TranquilMind:

The baby may well have sero-converted without all this poisonous treatment. 

It's happened regularly since the 80's.  Nothing new. 

Here's something I saw:

http://www.accessexcellence.org/WN/SUA03/hiv_baby_seroconverts.php


Are you a doctor? 

Then shut the f*ck up.




So wow. "I'm not a doctor(MD), but I play one in my mind. Because, hey, I've read about this!"

And so you feel perfectly justified to come on here & just throw out some biggg worrrrds you read about, like, ooooh aaaahhhhh: 'sero-converrrrrrsion.'

So I say again, STFU.




The substance I added was directed to you. I feel confident you comprehended it, even if you didn't address it, busy as you were with your ad hominem.




There are certain circumstances where I feel perfectly justified and have therefore given myself permission to unleash the Kraken of my sarcasm (pssst! Not the same as ad hominem!). You (general) are not spared of this if you:

  • Employ sloppy thinking
  • Are an ideologue
  • Spam up the group with multiple daily posts of similar theme (#2 are fond of this, and are therefore doubly targeted)
  • Are arrogant/lacking in humility
  • Come on a thread and post nonsensically, indicating they haven't read the OP/bothered to read the thread

There may be other categories, but these are the main ones. 

P.S: Your comment here began with #4 and then moved on to #1, in the form of an informal logical fallacy.

P.P.S: Logical fallacies can only happen when one is in an active debate/arguement, which we were and are not engaged in. I simply made a comment on a statement you made.

LindaClement
by Linda on Mar. 4, 2013 at 1:03 AM

I didn't know there were cops here...

Quoting Goodwoman614:



Quoting TranquilMind:

 Lol.  You just demonstrated that you are unfamiliar with the concept of ad hominem attack.    You leveled an ad hominem attack at me (impugning my credentials AND cursing me out) after I stated that sero-conversion is nothing new, as it has been documented for the last 30 years. 

Um, stating that this is nothing new, and citing a source is most decidedly NOT an ad hominem attack.  Telling someone to stfu because you have nothing substantive to add IS an ad hominem attack.  

 There is easy access to a dictionary online, if you are uncertain about a term.  Use it.  Comes in handy. 

And on that humorous note...time for bed. 

Quoting Goodwoman614:



Quoting TranquilMind:

 I see that reading comprehension is difficult for you, but you are well-versed in using vulgar curse words to distract from the fact that you have nothing substantive to add.   

I hope this serves you well.  


 

Quoting Goodwoman614:



Quoting TranquilMind:

 Well, I have a doctorate, but am not a medical doctor.  However, I can read research and have paid attention to this issue since it became big back in the 80's.  Mothering ran extensive articles on this back when they were arresting HIV positive Moms for breastfeeding.

I actually thought this might have been a substantive response.  I should know better.

  If you object to my idea, attack the idea.  Cussing me out does not bolster your position and it does discredit to your screen name, which I assume you think represents you.

Have a good night.


Quoting Goodwoman614:



Quoting TranquilMind:

The baby may well have sero-converted without all this poisonous treatment. 

It's happened regularly since the 80's.  Nothing new. 

Here's something I saw:

http://www.accessexcellence.org/WN/SUA03/hiv_baby_seroconverts.php


Are you a doctor? 

Then shut the f*ck up.




So wow. "I'm not a doctor(MD), but I play one in my mind. Because, hey, I've read about this!"

And so you feel perfectly justified to come on here & just throw out some biggg worrrrds you read about, like, ooooh aaaahhhhh: 'sero-converrrrrrsion.'

So I say again, STFU.




The substance I added was directed to you. I feel confident you comprehended it, even if you didn't address it, busy as you were with your ad hominem.




There are certain circumstances where I feel perfectly justified and have therefore given myself permission to unleash the Kraken of my sarcasm (pssst! Not the same as ad hominem!). You (general) are not spared of this if you:

  • Employ sloppy thinking
  • Are an ideologue
  • Spam up the group with multiple daily posts of similar theme (#2 are fond of this, and are therefore doubly targeted)
  • Are arrogant/lacking in humility
  • Come on a thread and post nonsensically, indicating they haven't read the OP/bothered to read the thread

There may be other categories, but these are the main ones. 

P.S: Your comment here began with #4 and then moved on to #1, in the form of an informal logical fallacy.

P.P.S: Logical fallacies can only happen when one is in an active debate/arguement, which we were and are not engaged in. I simply made a comment on a statement you made.


GotSomeKids
by Silver Member on Mar. 4, 2013 at 1:16 AM

This is promising, but I've heard of this in the early 90's.  Med probably better now.  I'm curious if there will be any long term side effects of such early treatment.

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