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Revealing Europe’s genetic history

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Revealing Europe’s genetic history
Migrations and an unexplained genetic turnover are part of modern Europe’s genetic history.

Ancient DNA recovered from a series of skeletons in central Germany up to 7500 years old has been used to reconstruct the first detailed genetic history of modern Europe.

The study, published in Nature Communications, reveals a dramatic series of events including major migrations from both Western Europe and Eurasia, and signs of an unexplained genetic turnover about 4000-5000 years ago.

The research was performed at the University of Adelaide's Australian Centre for Ancient DNA (ACAD). Researchers used DNA extracted from bone and teeth samples from prehistoric human skeletons to sequence a group of maternal genetic lineages that are now carried by up to 45% of Europeans.

The international team also included the University of Mainz in Germany and the National Geographic Society's Genographic Project.

"This is the first high-resolution genetic record of these lineages through time, and it is fascinating that we can directly observe both human DNA evolving in 'real-time', and the dramatic population changes that have taken place in Europe," says joint lead author Dr Wolfgang Haak of ACAD.

"We can follow over 4000 years of prehistory, from the earliest farmers through the early Bronze Age to modern times."

"The record of this maternally inherited genetic group, called Haplogroup H, shows that the first farmers in Central Europe resulted from a wholesale cultural and genetic input via migration, beginning in Turkey and the Near East where farming originated and arriving in Germany around 7500 years ago," says joint lead author Dr Paul Brotherton, formerly at ACAD and now at the University of Huddersfield, UK.

ACAD Director Professor Alan Cooper says: "What is intriguing is that the genetic markers of this first pan-European culture, which was clearly very successful, were then suddenly replaced around 4500 years ago, and we don't know why. Something major happened, and the hunt is now on to find out what that was."

The team developed new advances in molecular biology to sequence entire mitochondrial genomes from the ancient skeletons. This is the first ancient population study using a large number of mitochondrial genomes.

"We have established that the genetic foundations for modern Europe were only established in the Mid-Neolithic, after this major genetic transition around 4000 years ago," says Dr Haak. "This genetic diversity was then modified further by a series of incoming and expanding cultures from Iberia and Eastern Europe through the Late Neolithic."

"The expansion of the Bell Beaker culture (named after their pots) appears to have been a key event, emerging in Iberia around 2800 BC and arriving in Germany several centuries later," says Dr Brotherton. "This is a very interesting group as they have been linked to the expansion of Celtic languages along the Atlantic coast and into central Europe."

"These well-dated ancient genetic sequences provide a unique opportunity to investigate the demographic history of Europe," says Professor Cooper.

"We can not only estimate population sizes but also accurately determine the evolutionary rate of the sequences, providing a far more accurate timescale of significant events in recent human evolution."

The team has been working closely on the genetic prehistory of Europeans for the past 7-8 years.

Professor Kurt Alt (University of Mainz) says: "This work shows the power of archaeology and ancient DNA working together to reconstruct human evolutionary history through time. We are currently expanding this approach to other transects across Europe."

Genographic Project director Spencer Wells says: "Studies such as this on ancient remains serve as a valuable adjunct to the work we are doing with modern populations in the Genographic Project. While the DNA of people alive today can reveal the end result of their ancestors' ancient movements, to really understand the dynamics of how modern genetic patterns were created we need to study ancient material as well."

by on Apr. 28, 2013 at 1:12 PM
Replies (11-11):
by Gina on Apr. 29, 2013 at 4:02 PM
I've tried, but unless you can afford to subscribe, which I can't,lol, it doesn't get you very far. Both of my grandfathers died when my parents were very young, so we don't know much. And even with my grandmothers, well, one was the black sheep of the family and considered very scandalous, and the other I wasn't close to after my parents divorce. You know, I didn't find out until about 6 years ago that my paternal grandmother was the first if her family born here in the US, and that they were from Scotland. Until then, we had always been told that we had Irish blood, and we still might, but who knows? My maternal grandmother has always said that our grandfather had Native blood, and looking at his pictures it looks like it, but her family has always denied it, but then, I've since been told that that isn't unusual, especially from that time period. See, so many questions,lol.
Quoting Ziva65:


Quoting gludwig2000:

Very interesting, and there is nothing I would love more than to have my DNA tested, just because so much of my families history is lost.

We lost ours too in WW2. Via the Mormon website and old church records on microfilm, I go as far back as my great grandfather on my dads side. It's hard as country lines and languages change- still trying though :) Ancestry.dom has been great form my husbands side, but Americans and English people are pretty easy. Not really war torn like alot others... we did DNA testing for hubby's side and it did link us up to many other related people and now trying to ID the connections. It is really fascinating. I figure over time, we will learn even more. This already took about 20 years, and just keeps adding more info.


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