Hello ladies!

I've been wondering about this for some time.

This question is for mothers who are RH-. In other words you have no rh factor.

Is there anyone here that has NOT received the RhoGam DURING pregnancy.
If so, can you please tell me your reason for NOT getting it at 28 weeks.

I'm just comparing notes so to speak. I am leaning towards not getting it this time around. This is my 4th pregnancy and I have read too much on it that makes me NOT want to get it DURING my pregnancy.

(this following is not meant rudely) - Now, this is not a post for everyone to gang up on me and to tell me what RhoGam is for and how I'm huring my child if I don't have yada, yada, yada, it's pretty much a catch 22 whether you have it or not anyway.

I already know risks from HAVING it and NOT having it DURING pregnancy, I also DON'T trust everything the doctors or the pharmaceuticals company's put out as literature for these vaccines and RhoGam is a type of vaccine like it or not. I also know there is a lot of scary tactics by the pharmaceutical companies to get you to take the shot. Also it being a blood product you really never know what you are getting or putting into your body WHILE pregnant ("micro-filtered" or not!)

I know this is serious and I know the minor risks of the micro-bleeds, the antigens mixing and antibodies attacking the baby's RBCs, Sensitization, and Hemolytic disease (also called erythroblastosis fetalis).

And if there is some sort of trauma then yes, I would get the shot during my pregnancy but not otherwise. I will also have it after the birth if the baby's rh factor is "+".

I just want to know if there are other mothers out there that have skipped the shot at 28 weeks and why they decided to do.

Also, if you could share what your babies blood type was after he/she was born that would be awesome too.

So ladies please be cordial in your responses and treat others as you would like to be treated. I reserve the right to delete any hateful or demeaning comments, that is not what this is about. We can all discuss this as adults and accept what others choose to do with their bodies.

Thank you so much ladies, I greatly appreciate you letting me ask and I thank you in advance for all the help and stories you will throw my way.

Faithfully in Christ,

PS ... if you all could vote this popular so I could get other mother's to share I'd greatly appreciate!

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Feb. 29, 2008 at 12:30 PM i got the shot "(

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Feb. 29, 2008 at 12:59 PM I got the shots...but all my babies were born positive so it was a good decision for me.  I can certainly understand your concern for getting them though, anything that is a blood product is scarey now days.

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Feb. 29, 2008 at 1:04 PM

that wasn't an issue for me but i voted for this to be popular!.......good luck with all that!!!!.....it sounds scary to me!.....i agree about the docs and pharm co's trying ot scare us to use certain drugs/procedures

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Feb. 29, 2008 at 8:23 PM

I'm posting this so that way when people read it they know exactly what happens if the shot is not administered. I'm not gonna tell you to get it or not get it. I am RH- I had all the shots in both my pregnancies. Now because i moved i missed my shot but as soon as my new OBGYN found out my blood type then had me come in ASAP. I really didn't have a choice if i wanted them or not. But the chance of my anti-bodies harming my unborn child was enough for me to get them. I'd talk to your doctor and see what they say.

When an Rh-negative woman carries an Rh-positive baby, small numbers of the baby’s red blood cells may get into the mother’s bloodstream. This can happen during your pregnancy as well as at delivery. The mother’s immune system sees the baby’s Rh-positive red blood cells as foreign and goes to work to produce antibodies against them.

Yes. The antibodies formed to protect you against Rh-positive red blood cells can pass to the baby you are carrying. They attack and destroy the baby’s Rh-positive red blood cells, causing anemia (low red blood cell count), jaundice, and in sever cases, heart failure. This condition is known as hemolytic disease of the newborn, or HDN.

HDN usually does not affect the mother’s first baby, but once she has produced Rh antibodies, all future Rh-positive babies are at risk. RhoGAM Ultra-Filtered PLUS prevents the production of these antibodies.


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Mar. 1, 2008 at 2:52 AM

My understanding is that not getting the shot affects a FUTURE pregnancy, not the one you are in. 

Anyway, to answer.  I am O-.  I received the shot during and after my first pregnancy (A+).  I did NOT recieve it during my second pregnancy but did after (O+).  Third pregnancy was miscarried at 4 weeks, so no shot yet.  Fourth pregnancy, got the shot during, not after because baby shared my blood type.  

I plan on one more pregnancy...I'm still sort of torn on it.  I probably WOULDN'T get it during my next pregnancy.  HTH 

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Mar. 1, 2008 at 8:49 AM

Well I wasn't going to do this since I asked for mothers to share their reasons why they don't want to or didn't get the shot but I feel it only fair to show both sides of the coin.

Again I'm not opposed to RhoGam AFTER the birth if baby types "+" but if the baby doesn't and you are carrying a "rh-" baby and lets say for the sake of the argument you DO have a trauma or even just bleeding ... if you get the shot during pregnancy ... you are actually putting in you EXACTLY what you don't want to be there ANTIBODIES that will attack the baby's RBC. RhoGam is a double edge sword and everyone must make their own decision. This is not the only reason I have for doubting the shot DURING pregnancy, but just one that makes sense .... and remember the shot will stay in you AND THE BABY for 12-14 weeks after administered 


DANGERS with RHOGAM given DURING pregnancy

I collection of information I & others have put together.........

You have to research MUCH on your own and come to your own decision

Important point about RhoGam and that is that the antibodies attack ALL RH
positive cells.  If mother's blood mixes with the baby's blood, the
antibodies will neutralize the baby's blood cells before the mother can
create her own antibodies against the baby. The dilemna is that if the
mother's and baby's blood does actually mix it is equally likely that the
RhoGam antibodies will cross over and attack the baby itself. This happens
frequently but isn't discussed by most doctors.

*******It is a big reason to only get the shot after pregancy if the baby
really is RH+  ************

The RhoGam antibodies will attach to your baby's blood cells and render
them incapable of delivering oxygen. This has long term consequences on
brain development. My doctor was completely ignorant of this issue.

The RhoGam antibodies do not cross the placenta. But neither do blood cells
from the baby which is exactly why the RhoGam is injected. In very rare
circumstances, such as the mother becoming injured, the blood of the mother
and baby can mix. It's a paradox, only when the antibodies are needed can
they harm the baby.

The RhoGam antibodies are put there to attack any baby's blood that comes
across. But if there is mixing then the antibodies can go across the other
way and they do exactly that. Antibodies diffuse much more readily through
the bloodstream than whole cells.

Immunology textbooks still correctly point out that RhoGam should be given
after childbirth only if the baby is RH+. These are the mothers that are at
high risk.

However the company that manufactures RhoGam lobbied to have it's use
expanded to all RH- mothers during and after pregnancy to 'guarantee' that
all high risk mothers were protected.

Doctors try to rationalize this by saying that even during the first
pregnancy blood can mix and antibodies can be produced that will attack the
baby. This almost never happens because the blood would have to mix twice,
once to stimulate the production of Abs in the mother and the second time
for those antibodies to diffuse to the baby. And regardless, the paradox
comes into play because if the mother's antibodies can diffuse to harm the
baby, then so can the injected RhoGam antibodies. They are the same exact
antibodies. Ask your doctor how your anti-RH antibodies were more harmful
than other mother's anti-RH antibodies (in Rhogam) . They will not
comprehend what you are talking about.

RhoGam after pregnancy - childbirth is what causes the blood to mix and,
when given at this time, RhoGam can prevent stimulation of the mother's
immune system. There is no reason to give RhoGam during pregnancy except to
increase profits for the manufacturer because RH- mothers with RH- babies
will also get the injection even though they couldn't possibly need it.

Each RhoGam injected contains blood serum pooled from several different
persons with the antibodies. The manufacturer can not possibly screen or
remove all viruses from it. But that's a separate issue.

 You would need a blood transfusion from an RH+ person to stimulate the
production of antibodies against RH factor. You will not find a single case
in the scientific literature of an RH- person who seroconverted after
minimal blood contact with an RH+ person.

The shot does work after pregnancy when it can not possibly harm the baby.
It offers NO additional benefit during pregnancy. The safety concern during
pregnancy is real. Does it make sense to you to inject antibodies into the
mother's blood stream that are designed for the sole purpose to eliminate
cells of the baby? There are numerous case reports of babies born anoxic
and asphyxiated because the RHoGam antibodies crossed the placenta during
the gestation period. This is not the only safety concern with the
injection, just the most obvious.

I hope this comes across clearly: the reason that it is a risk for RH-
mothers to carry RH+ babies is that the mother could produce antibodies to
her own child. If those antibodies are in her blood while she is pregnant
there is a small chance that they will come into contact with and harm the
baby. Rhogam during pregnancy guarantees those antibodies will be there. It
does not matter if the mother made the antibodies or if they were injected,
the baby is now at risk for attack from RH+ antibodies. The original point
of saving the baby from antibody attack has been abrogated by giving rhogam
during gestation.

Rhogam antibodies against the baby and antibodies produced by the RH-
mother are identical. If the whole point is to prevent these antibodies
from circulating in the mother during pregnancy, why on Earth would you
inject them into the mother exactly when she is pregnant.

The antibodies are intended to protect the second pregnancy by preventing
sensitization. If sensitization were to occur and the second baby were rh+
then you would have antibodies circulating in your blood against your own
baby. This would only be a problem if the blood mixed.

The problem is that injecting Rhogam during gestation you are getting
protection for your second pregnancy at the expense of your first. If you
put Rhogam antibodies into your body during your first pregnancy you are
putting antibodies against your baby into your blood stream where, if blood
mixing does occur, those antibodies will attack your baby. This is exactly
what you are trying to avoid for the second pregnancy. So, in reality you
are protecting your second pregnancy from the antibodies by injecting them
into yourself during the first pregnancy. I can't state it any better than
this: if you inject Rhogam durng your first pregnancy you will prevent a
potentially harmful situation for your next pregnancy by causing that exact
same harmful situation in your first pregnancy.

The company that makes the injection decided that the shot should be given
during gestation to increase profits. It increases profits becasue rh-
mothers carrying rh- babies are also getting the injection. The company has
just doubled its sales of Rhogam through a minor lobbying effort. Great
business decision - poor health decision. They convinced the government
agencies to support the expanded role of Rhogam who then recommended it for
all rh- negative pregnancies. Doctors follow the government recommendations
without question. Doctors do not make the decisions, they follow orders.

Rhogam works just fine if you get it immediately after you deliver when it
can't harm the baby. You can get Rhogam without mercury.

The Rhogam antibodies are identical to the antibodies that the Rh- mother
makes against her child. The Rhogam antibodies were collected from RH-
mothers who did have an immune response to their RH+ babies. The Rhogam
antibodies will attack and destroy the baby's red blood cells (if they do
come across the placenta) before the mother's immune response kicks in and
makes her own antibodies. You give rhogam to a mother after delivery
becasue that is when the blood mixes. The rhogam antibodies destroy the
baby's cells so that the mother's immune system never sees them and
therefore never becomes sensitized to make those exact same antibodies. If
you give the Rhogam antibodies during pregnancy you have just created the
situation you were trying to avoid. The whole point is for the pregnant
mother to NOT have antibodies against her own child circulating in her
system while she is pregnant. Any blood mixing would allow those antibodies
to attack the baby. It does not matter if the mother's immune system made
those antibodies or another mother's immune system (rhogam) made those
antibodies. They are identical down to their molecular structure and you do
not want them to contact the baby.

In fact, we can refer to the mother's immune response against her baby as
rhogam production since that's exactly what it is:
The rh+ cells of the baby stimulate rhogam production by the rh-mother's
immune system. We want to prevent rhogam from circulating in the mother
while she is pregnant because those antibodies will harm the baby. To do
this we give rhogam immediately after birth so that any rh+ cells that are
still in the mother will be destroyed. This keeps the mother's immune
system from seeing those cells and producing her own rhogam which would
stay in her circulation where they could attack any subsequent rh+ babies.
Doctors would like us to inject rhogam antibodies during pregnancy to
prevent the formation of rhogam antibodies. The rhogam will destroy all the
rh+ cells thus preventing the mother from making her own rhogam antibodies.
But what's the point, you prevented the mother's antibodies from being
there by putting someone else's antibodies in the exact same spot. This is
the point which I am Rhogam is the immune response to the baby. It is the
pooled serum from rh- mother's who have had an immune response to their rh+
babies. You do not want those antibodies to come into contact with your rh+

EUROPE only administers after pregnancy!  During pregnancy is a decision
that was made by the manufacturer to make money.
If a woman has a miscarriage she should have the shot immediately. If there
is an amniocentesis performed it may be worth while to have the injection
but there is some risk to that. It makes no sense to give the injection at
28 weeks during a healthy pregnancy. The blood does not mix in a sufficient
manner to cause an immune response in the mother. If there were that much
mixing then the injected antibodies (rhogam) would have access to the baby
and kill the baby's red blood cells. It's a no win situation with rhogam at
28 weeks. The reason the manufacturer can get away with it is exactly
because there is no blood mixing. The rhogam works it's way out of the
mother's system without ever doing anything.

Another way to look at rhogam. Rhogam kills the baby's red blood cells no
matter where those cells are. If the baby's blood cells are in the mother,
those cells will be destroyed. If the baby's red blood cells are
circulating through the baby delivering oxygen to the baby's brain, the
rhogam will still kill those cells and deprive the baby of oxygen. It is
not a good idea to take any chance that would allow the rhogam access to
the baby. The doctors are concerned only about baby's cells circulating in
the mother but antibodies diffuse much more easily than whole cells so the
rhogam will readily find the baby's cells where the baby is than for the
whole cells of the baby to find their way to the rhogam.

Again, You have to research MUCH on your own and come to your own decision
I can only share what makes sense to me.


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Feb. 4, 2013 at 5:35 AM


I am 15 weeks pregnant and doctor told me about the injection today...my husband is doubtful about it and so i started to look for some info. Then I come across your post and it is not so clear any more. What you write makes a lot of sense. My first pregnancy ended in miscarriage at 7 weeks...i had no injection given. My blood type is 0-, my husband's AB+....no clue what i should do...

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